Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4Rα-Jak1-STAT6 and Jagged1/Jagged2 -Notch1/Notch2 pathways in asthmatic mice

Author:

Chen Bin Lin12,Chen Yan Qiu3,Ma Bai Hui12,Yu Si Fei4,Li Li Yue56,Zeng Qing Xiang3,Zhou Yu Tao56,Wu Yin Fan12,Liu Wen long3ORCID,Wan Jian Bo7,Yang Yan12,Li Chun Wei56ORCID

Affiliation:

1. School of Public Health (Shenzhen); Sun Yat-sen University; Guangzhou China

2. Guangdong Provincial Key Laboratory of Food, Nutrition and Health; School of Public Health; Sun Yat-sen University (Guangzhou Campus); Guangzhou China

3. Department of Otolaryngology; Guangzhou Women and Children Medical Centre; Guangzhou China

4. Institute of Immunology; Zhongshan School of Medicine; Sun Yat-sen University; Guangzhou China

5. Department of Otolaryngology; The First Affiliated Hospital; Sun Yat-sen University; Guangzhou China

6. Guangzhou Key Laboratory of Otorhinolaryngology; The First Affiliated Hospital; Sun Yat-sen University; Guangzhou China

7. State Key Laboratory of Quality Research in Chinese Medicine; Institute of Chinese Medical Sciences; University of Macau; Macau China

Funder

Fundamental Research Funds for the Central Universities

Guangzhou Science and Technology Program key projects

Natural Science Foundation of Guangdong Province

National Natural Science Foundation of China

Guangdong Provincial Medical Science and Technology Research Fund

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

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