Affiliation:
1. Intensive Care Unit Afyonkarahisar Health Sciences University Afyonkarahisar Turkey
2. Department of Anesthesiology and Reanimation, Intensive Care Unit SBU Tepecik Training and Research Hospital İzmir Turkey
3. Department of Neurology Afyonkarahisar Health Sciences University Afyonkarahisar Turkey
4. Department of İnternal Medicine Afyonkarahisar Health Sciences University Afyonkarahisar Turkey
5. Department of Chest Diseases Afyonkarahisar Health Sciences University Afyonkarahisar Turkey
Abstract
AbstractAimTo evaluate the inflammatory parameters and oxygenation in severe coronavirus disease‐19 patients who underwent extracorporeal cytokine adsorption (CA).MethodsPatients who underwent extracorporeal CA for cytokine storm were included in the study. The changes in oxygenation, laboratory parameters, and mortality rates were investigated.ResultsThirty‐six patients were included in the study. The hemoglobin, thrombocyte, and C‐reactive protein (CRP) decreased, and PaO2/FiO2 ratio increased (p < 0.001; p < 0.01; p < 0.001; p = 0.04, respectively). Twelve (33.3%) patients received a single session, 24 (66.6%) received 2 or more sessions. CRP and fibrinogen levels decreased, and PaO2/FIO2 ratio increased in the single session group (p = 0.04; p = 0.04; p = 0.01, respectively). In the multi‐session group, the hemoglobin, platelet, procalcitonin, and CRP levels decreased, and PaO2/FIO2 ratio increased (p < 0.01; p = 0.02; p = 0.02; p < 0.01; p = 0.01, respectively). Day 15, 30, and 90 mortality rates were 61.1%, 83.3%, and 88.9%.ConclusionCA with hemoperfusion reduced CRP and improved oxygenation; however, mortality rates were high.