Author:
Yamamoto E.,Ino K.,Yamamoto T.,Sumigama S.,Nawa A.,Nomura S.,Kikkawa F.
Abstract
Nongestational pure choriocarcinoma of the ovary is a very rare germ cell tumor. Except in women before menarche, determination of the origin is very difficult without genetic analysis. We present a pure nongestational choriocarcinoma arising in the left ovary of a 19-year-old woman. Following surgery, pathologic findings of the tumor demonstrated pure choriocarcinoma without combination of other germ cell tumor elements. We confirmed its nongestational origin by DNA polymorphism analysis at 15 short tandem repeat loci. Multiple courses of chemotherapy with methotrexate, etoposide, and actinomycin-D were effective for this case. DNA polymorphism analysis is useful to determine genetic origin in pure choriocarcinoma of the ovary
Subject
Obstetrics and Gynecology,Oncology
Reference10 articles.
1. Malignant trophoblastic neoplasms with different modes of origin;Arima;Cancer Genet Cytogenet,1995
2. DNA polymorphism analysis of a pure non-gestational choriocarcinoma of the ovary: case report;Shigematsu;Eur J Gynaecol Oncol,2000
3. A pure nongestational choriocarcinoma of the ovary diagnosed with DNA polymorphism analysis;Tsujioka;Gynecol Oncol,2003
4. Studies on the pathogenesis of choriocarcinoma by analysis of restriction fragment length polymorphisms;Azuma;Cancer Res,1990
5. Gestational and nongestational trophoblastic tumors distinguished by DNA analysis;Fisher;Cancer,1992
Cited by
39 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献