Feeling of incomplete bladder emptying and angiogenesis‐related polymorphism rs3025020 among older community‐dwelling individuals

Abstract

AimTo clarify the association between genetic factors related to angiogenesis and feeling of incomplete bladder emptying among older community‐dwelling individuals.MethodA cross‐sectional study of 1762 (607 men and 1155 women) older Japanese individuals aged 60–79 years with data on rs3025020 was conducted, because vascular endothelial growth factor (VEGF), which contributes to the progression of angiogenesis, has been reported to be positively associated with the minor allele (T) of polymorphism rs3025020.ResultsIn the study population, 155 (103 men and 52 women) had feeling of incomplete bladder emptying. With rs3025020 (C/C) as the reference group, rs3025020 (T/T) was associated with a significantly higher odds ratio (OR) for feeling of incomplete bladder emptying. The adjusted ORs and 95% confidence intervals were 3.01(1.53, 5.93) in men and 2.48 (1.09, 5.66) in women, respectively.ConclusionVEGF polymorphism rs3025020 was associated with feeling of incomplete bladder emptying among older community‐dwelling individuals. Development of angiogenesis could be associated with feeling of incomplete bladder emptying in older individuals. Geriatr Gerontol Int 2024; ••: ••–••.