Phosphorylation of tau protein at sites Ser396-404is one of the earliest events in Alzheimer's disease and Down syndrome

Author:

Mondragón-Rodríguez S.1,Perry G.23,Luna-Muñoz J.4,Acevedo-Aquino M. C.5,Williams S.1

Affiliation:

1. Douglas Hospital Research Center; Department of Psychiatry; McGill University; Montreal Quebec Canada

2. UTSA Neurosciences Institute and Department of Biology; College of Sciences; University of Texas at San Antonio; San Antonio TX USA

3. Department of Pathology; Case Western Reserve University; Cleveland OH USA

4. Departments of Physiology, Biophysics and Neurosciences; CINVESTAV-IPN; Mexico D.F. Mexico

5. Faculty of Medicine; Université de Montréal; Montreal Quebec Canada

Publisher

Wiley

Subject

Physiology (medical),Clinical Neurology,Neurology,Histology,Pathology and Forensic Medicine

Reference38 articles.

1. Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells;Pickhardt;J Biol Chem,2005

2. Amyloid Beta and tau proteins as therapeutic targets for Alzheimer's disease treatment: rethinking the current strategy;Mondragon-Rodriguez;Int J Alzheimers Dis,2012

3. Drugs: a tangled web of targets;Gravitz;Nature,2011

4. Causes versus effects: the increasing complexities of Alzheimer's disease pathogenesis;Mondragon-Rodriguez;Expert Rev Neurother,2010

5. Positron emission tomography of brain beta-amyloid and tau levels in adults with Down syndrome;Nelson;Arch Neurol,2011

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