Defining critical residues for substrate binding to 1-deoxy-d-xylulose 5-phosphate synthase - active site substitutions stabilize the predecarboxylation intermediate C2α-lactylthiamin diphosphate
Author:
Affiliation:
1. Department of Pharmacology and Molecular Sciences; The Johns Hopkins University School of Medicine; Baltimore MD USA
2. Department of Chemistry; Rutgers University; Newark NJ USA
Funder
National Institutes of Health
Publisher
Wiley
Subject
Cell Biology,Molecular Biology,Biochemistry
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/febs.12823/fullpdf
Reference29 articles.
1. Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-d-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol;Sprenger;Proc Natl Acad Sci USA,1997
2. Cloning and characterization of a gene from Escherichia coli encoding a transketolase-like enzyme that catalyzes the synthesis of d-1-deoxyxylulose 5-phosphate, a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis;Lois;Proc Natl Acad Sci USA,1998
3. Biosynthesis of vitamins B1 and B6 in Escherichia coli: concurrent incorporation of 1-deoxy-d-xylulose into thiamin (B1) and pyridoxol (B6);Himmeldirk;Chem Commun,1996
4. The biogenetic anatomy of vitamin B6. A 13C NMR investigation of the biosynthesis of pyridoxol in Escherichia coli;Hill;J Biol Chem,1996
5. The nonmevalonate pathway of isoprenoid biosynthesis in Mycobacterium tuberculosis is essential and transcriptionally regulated by Dxs;Brown;J Bacteriol,2010
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