Affiliation:
1. Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences The University of Tokyo Tokyo Japan
Abstract
AbstractChromatin is the fundamental structure of genomic DNA in eukaryotic cells. The nucleosome, the primary unit of chromatin, consists of DNA and histone proteins, and is important for the maintenance of genomic DNA. Histone mutations are present in many types of cancers, suggesting that chromatin and/or nucleosome structures could be closely related to cancer development. Histone modifications and histone variants are also involved in regulating chromatin and nucleosome structures. Chromatin structures are dynamically changed by nucleosome binding proteins. In this review article, we discuss the current progress toward understanding the relationship between chromatin structure and cancer development.
Funder
Exploratory Research for Advanced Technology
Japan Agency for Medical Research and Development
Japan Society for the Promotion of Science
Precursory Research for Embryonic Science and Technology
Subject
Cancer Research,Oncology,General Medicine