Clinical Practice Guidelines for Hepatocellular Carcinoma: The Japan Society of Hepatology 2021 version (5th JSH‐HCC Guidelines)

Author:

Hasegawa Kiyoshi1ORCID,Takemura Nobuyuki2ORCID,Yamashita Tatsuya3,Watadani Takeyuki4ORCID,Kaibori Masaki5,Kubo Shoji6,Shimada Mitsuo7,Nagano Hiroaki8ORCID,Hatano Etsuro9ORCID,Aikata Hiroshi10,Iijima Hiroko11,Ueshima Kazuomi12ORCID,Ohkawa Kazuyoshi13ORCID,Genda Takuya14ORCID,Tsuchiya Kaoru15,Torimura Takuji16,Ikeda Masafumi17ORCID,Furuse Junji18,Akahane Masaaki19,Kobayashi Satoshi20ORCID,Sakurai Hideyuki21,Takeda Atsuya22,Murakami Takamichi23ORCID,Motosugi Utaroh24,Matsuyama Yutaka25,Kudo Masatoshi12,Tateishi Ryosuke26,

Affiliation:

1. Hepato‐Biliary‐Pancreatic Surgery Division Department of Surgery Graduate School of Medicine University of Tokyo Tokyo Japan

2. Department of Surgery Hepato‐Biliary Pancreatic Surgery Division National Center for Global Health and Medicine Tokyo Japan

3. Department of Gastroenterology Kanazawa University Hospital Kanazawa Japan

4. Department of Radiology Graduate School of Medicine The University of Tokyo Tokyo Japan

5. Department of Surgery Hirakata Hospital Kansai Medical University Hirakata Japan

6. Department of Hepato‐Biliary‐Pancreatic Surgery Osaka Metropolitan University Graduate School of Medicine Osaka Japan

7. Department of Digestive and Transplant Surgery Tokushima University Hospital Tokushima Japan

8. Department of Gastroenterological, Breast and Endocrine Surgery Yamaguchi University Graduate School of Medicine Yamaguchi Japan

9. Division of Hepato‐Biliary‐Pancreatic Surgery and Transplantation Department of Surgery Graduate School of Medicine Kyoto University Kyoto Japan

10. Department of Medicine and Molecular Science Hiroshima University Hospital Hiroshima Japan

11. Division of Gastroenterology and Hepatobiliary Department of Internal Medicine Hyogo Medical University Nishinomiya Japan

12. Department of Gastroenterology and Hepatology Kindai University Faculty of Medicine Higashi‐osaka Japan

13. Department of Hepatobiliary and Pancreatic Oncology Osaka International Cancer Institute Osaka Japan

14. Department of Gastroenterology and Hepatology Juntendo University Shizuoka Hospital Izunokuni Japan

15. Department of Gastroenterology and Hepatology Musashino Red Cross Hospital Musashino Japan

16. Division of Gastroenterology Department of Medicine Kurume University School of Medicine Kurume Japan

17. Department of Hepatobiliary and Pancreatic Oncology National Cancer Center Hospital East Kashiwa Japan

18. Department of Gastroenterology Kanagawa Cancer Center Yokohama Japan

19. Department of Radiology School of Medicine International University of Health and Welfare Otawara Japan

20. Department of Quantum Medical Technology Kanazawa University Graduate School of Medical Sciences Kanazawa Japan

21. Department of Radiation Oncology University of Tsukuba Faculty of Medicine Tsukuba Japan

22. Radiation Oncology Center Ofuna Chuo Hospital Kamakura Japan

23. Department of Radiology Kobe University Graduate School of Medicine Hyogo Japan

24. Department of Diagnostic Radiology Kofu Kyoritsu Hospital Kofu Japan

25. Department of Biostatistics School of Public Health Graduate School of Medicine The University of Tokyo Tokyo Japan

26. Department of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo Japan

Abstract

AbstractThe fifth version of the Clinical Practice Guidelines for Hepatocellular Carcinoma was revised by the Japan Society of Hepatology, according to the methodology of evidence‐based medicine and partly to the Grading of Recommendations Assessment, Development and Evaluation system, which was published in October 2021 in Japanese. In addition to surveillance–diagnostic and treatment algorithms, a new algorithm for systemic therapy has been created, as multiple drugs for hepatocellular carcinoma can be currently selected. Here, new or revised algorithms and evidence on which the recommendations are based are described.

Publisher

Wiley

Subject

Infectious Diseases,Hepatology

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