Affiliation:
1. Department of Anatomy Tokyo Dental College Tokyo Japan
2. Department of Anatomy, Division of Basic Medicine Tokai University School of Medicine Isehara Japan
3. Department of Otolaryngology‐Head and Neck Surgery Tohoku University Graduate School of Medicine Sendai Japan
4. Division of Internal Medicine Cupid Clinic Iwamizawa Japan
5. Department of Anatomy and Embryology School of Medicine, Complutense University Madrid Spain
Abstract
AbstractRecent molecular biology studies have revealed the process of nasal capsule determination. We aimed to create a fate map showing the association between the adult and embryonic components of the nasal wall and nasal capsule derivatives. We examined paraffin‐embedded histological sections between 15 mid‐term (9–16 weeks) and 12 near‐term (27–40 weeks) foetuses. Until 15 weeks, membranous ossification occurred ‘along’ the capsular cartilage, contributing to the formation of the vomer, maxilla and bony nasal septum as well as the nasal, frontal and lacrimal bones. After 15 weeks, a wide lateral part of the capsule became thin and fragmented, and degenerative cartilage was observed near the lacrimal bone, in the three conchae, and at the inferolateral end of the capsule sandwiched between the maxilla and palatine bone. The disappearing cartilages appeared to be replaced by nearby membranous bones. This type of membranous ossification did not appear to use the capsular cartilage as a ‘mould’, although the perichondrium may have a role in inducing ossification. Calcified cartilage indicated endochondral ossification in the inferior concha until 15 weeks and, later, at the bases of three conchae and around the future sphenoid sinus (i.e. the concha sphenoidalis). The capsular cartilage extended antero‐superiorly over the frontal bone and inserted into the nasal bone. At 40 weeks, the capsular cartilage remained in the cribriform plate and at the inferolateral end along the palatine bone. Consequently, less guidance from the nasal capsule seemed to provide great individual variation in the shape of the wide anterolateral wall of the nasal cavity.
Funder
Japan Society for the Promotion of Science
Subject
Cell Biology,Developmental Biology,Molecular Biology,Ecology, Evolution, Behavior and Systematics,Histology,Anatomy
Cited by
2 articles.
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