Genomewide association study identifies a novel variant associated with tacrolimus trough concentration in Chinese renal transplant recipients

Author:

Yang Siyao1ORCID,Jiang Haixia2,Li Chengcheng1ORCID,Lu Huijie1ORCID,Li Chuanjiang3ORCID,Ye Demei1,Qi Huana1,Xu Wenbin1,Bao Xiaojie1,Maseko Nicola1,Zhang Siqi1ORCID,Shao Ruifan1,Li Liang14ORCID

Affiliation:

1. Department of Medical Genetics, School of Basic Medical Sciences Southern Medical University Guangzhou Guangdong China

2. Department of Laboratory Medicine, Nanfang Hospital, The First School of Clinical Medicine Southern Medical University Guangzhou Guangdong China

3. Division of Hepatobiliopancreatic Surgery, Department of General Surgery, Nanfang Hospital, The First School of Clinical Medicine Southern Medical University Guangzhou Guangdong China

4. Experimental Education and Administration Center, School of Basic Medical Sciences Southern Medical University Guangzhou Guangdong China

Funder

Southern Medical University

Basic and Applied Basic Research Foundation of Guangdong Province

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Reference38 articles.

1. FK506 in clinical organ transplantation;Fung JJ;Clin Chem,1993

2. FK506, An Immunosuppressant Targeting Calcineurin Function

3. Clinical Pharmacokinetics and Pharmacodynamics of Tacrolimus in Solid Organ Transplantation

4. Tacrolimus versus cyclosporin as primary immunosuppression for kidney transplant recipients;Webster A;Cochrane Database Syst Rev,2005

5. Two decades of tacrolimus in renal transplant: basic science and clinical evidences;Shrestha BM;Exp Clin Transplant,2017

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