20S constitutive proteasome, 20S immunoproteasome, and cathepsin S are high‐sensitivity and independent markers of immunological activity in relapsing‐remitting type of multiple sclerosis

Author:

Górska Ewelina123,Tylicka Marzena4ORCID,Kamińska Joanna5ORCID,Hermanowicz Adam2,Matuszczak Ewa2,Ołdak Łukasz3,Gorodkiewicz Ewa3,Karpińska Elżbieta6,Socha Katarzyna6,Kochanowicz Jan7,Jakoniuk Marta8,Homšak Evgenija910,Koper‐Lenkiewicz Olga Martyna5

Affiliation:

1. Neurological Private Practice Bialystok Poland

2. Department of Pediatric Surgery Medical University of Bialystok Bialystok Poland

3. Bioanalysis Laboratory, Faculty of Chemistry University of Bialystok Bialystok Poland

4. Department of Biophysics Medical University of Bialystok Bialystok Poland

5. Department of Clinical Laboratory Diagnostics Medical University of Bialystok Bialystok Poland

6. Department of Bromatology Medical University of Białystok Białystok Poland

7. Department of Neurology Medical University of Białystok Białystok Poland

8. Department of Invasive Neurology Medical University of Białystok Białystok Poland

9. Department for Laboratory Diagnostics University Clinical Centre Maribor Maribor Slovenia

10. Department for Clinical Biochemistry Medical Faculty, University Maribor Maribor Slovenia

Abstract

AbstractResearch on the markers of autoimmune response in multiple sclerosis (MS) is still of great importance. The aim of our study was the evaluation of plasma 20S constitutive proteasome, 20S immunoproteasome, and cathepsin S concentrations as potential biomarkers of a relapsing‐remitting type of MS (RRMS). Surface plasmon resonance imaging (SPRI) biosensors were used for the evaluation of protein concentrations. Plasma 20S constitutive proteasome, 20S immunoproteasome, and cathepsin S concentrations were significantly higher in RRMS patients compared to the control group. All three parameters were characterized by excellent usefulness in differentiating MS patients from healthy individuals (AUC equal to or close to 1.000). The plasma concentration of analyzed parameters was not correlated with severity of disability in the course of RRMS (EDSS value), the number of years from the first MS symptoms, the number of years from MS diagnosis, or the number of relapses within the 24‐month observational period. Our study has shown that plasma concentrations of 20S constitutive proteasome, 20S immunoproteasome, and cathepsin S have promising potential in differentiating RRMS patients from healthy individuals. All of the analyzed parameters were found to be independent of the time of MS relapse and the severity of neurological symptoms. Hence, their potential as highly sensitive and independent circulating markers of RRMS suggests a stronger association with immunological activity (inflammatory processes) than with the severity of the disease.image

Publisher

Wiley

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