Bile acids induce activation of alveolar epithelial cells and lung fibroblasts through farnesoid X receptor-dependent and independent pathways

Author:

Chen Bi1,Cai Hou-Rong2,Xue Shan1,You Wen-Jie1,Liu Bin1,Jiang Han-Dong1

Affiliation:

1. Department of Respiratory Medicine, Ren Ji Hospital, School of Medicine; Shanghai Jiao Tong University; Shanghai China

2. Department of Respiratory Medicine; the Affiliated Drum Tower Hospital of Nanjing University Medical School; Nanjing China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Pulmonary and Respiratory Medicine

Reference37 articles.

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2. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix;Kim;Proc. Natl. Acad. Sci. U. S. A.,2006

3. Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis;Willis;Am. J. Pathol.,2005

4. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis;Kim;J. Clin. Invest.,2009

5. Inhibition of epithelial-to-mesenchymal transition and pulmonary fibrosis by methacycline;Xi;Am. J. Respir. Cell Mol. Biol.,2014

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