Aquaporin-4 Knockout Exacerbates Corticosterone-Induced Depression by Inhibiting Astrocyte Function and Hippocampal Neurogenesis

Author:

Kong Hui12,Zeng Xiao-Ning12,Fan Yi2,Yuan Song-Tao2,Ge Song3,Xie Wei-Ping1,Wang Hong1,Hu Gang2

Affiliation:

1. Department of Respiratory Medicine; The First Affiliated Hospital of Nanjing Medical University; Nanjing China

2. Jiangsu Key Laboratory of Neurodegeneration; Department of Pharmacology; Nanjing Medical University; Nanjing China

3. Department of Neurology; The First Affiliated Hospital of Nanjing Medical University; Nanjing China

Publisher

Wiley

Subject

Pharmacology (medical),Physiology (medical),Psychiatry and Mental health,Pharmacology

Reference59 articles.

1. Glucocorticoids, cytokines and brain abnormalities in depression;Zunszain;Prog Neuropsychopharmacol Biol Psychiatry,2011

2. Synaptic dysfunction in depression: Potential therapeutic targets;Duman;Science,2012

3. Astrocyte pathology in major depressive disorder: Insights from human postmortem brain tissue;Rajkowska;Curr Drug Targets,2013

4. Glial loss in the prefrontal cortex is sufficient to induce depressive-like behaviors;Banasr;Biol Psychiatry,2008

5. Hippocampal astrocytes are necessary for antidepressant treatment of learned helplessness rats;Iwata;Hippocampus,2011

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