Affiliation:
1. Department of Skin & Cosmetic Research Shanghai Skin Disease Hospital Skin Disease Hospital of Tongji University Shanghai China
2. Clinical Research Center Shanghai Skin Disease Hospital Skin Disease Hospital of Tongji University Shanghai China
3. Bloomage Biotech Co., Ltd Jinan Shandong China
Abstract
AbstractObjectiveTo evaluate the impact of oral intake of Hyaluronic Acid (HA) on skin health.BackgroundHA, an endogenous substance in the human body, plays a key role in skin health. However, its concentration in the skin decreases significantly with age. Previous studies suggested that oral intake of HA can supplement the body's HA level, but did not reveal the effects on different age groups and skin types.MethodsA double‐blind, randomized clinical trial with 129 female participants, covering young and elderly groups and differnet skin types, was conducted to assess the efficacy of orally administered HA on skin health.ResultsOral administration of HA significantly promoted skin hydration after 2‐8 weeks among both young and elderly groups. Skin tone improvement was observed after 4‐8 weeks, while an increase in epidermal thickness was noted after 12 weeks.ConclusionThis study provides direct evidence supporting the clinical efficacy of oral intake of HA in promoting skin health.