Detection of two distinct public specificities on HLA‐A28 bearing lymphocytes

Abstract

We have used the antiglobulin augmented cytotoxicity assay and platelet absorption‐elution techniques to investigate crossreactivity among certain antigens coded by the HLA‐A locus. These serologic and absorption studies demonstrated two supertypic determinants, distinct from private determinants, associated with HLA‐A locus gene products. One determinant was present on HLA‐A2, Aw23, Aw24, and A28 bearing lymphocytes; the other was found on HLA‐A28, Aw33, Aw34, and A26 bearing lymphocytes. The second determinant was not associated with HLA‐A25. Both supertypic determinants are associated with HLA‐A28.