Efficacy and safety of treatment with biologicals (benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab) for severe eosinophilic asthma. A systematic review for the EAACI Guidelines ‐ recommendations on the use of biologicals in severe asthma

Author:

Agache Ioana1ORCID,Beltran Jessica2,Akdis Cezmi34ORCID,Akdis Mubeccel3ORCID,Canelo‐Aybar Carlos25,Canonica Giorgio Walter6,Casale Thomas7ORCID,Chivato Tomas8,Corren Jonathan9,Del Giacco Stefano10,Eiwegger Thomas111213ORCID,Firinu Davide10ORCID,Gern James E.14,Hamelmann Eckard15ORCID,Hanania Nicola16,Mäkelä Mika17,Hernández‐Martín Irene18,Nair Parameswaran1920ORCID,O'Mahony Liam21ORCID,Papadopoulos Nikolaos G.2223ORCID,Papi Alberto24,Park Hae‐Sim25ORCID,Pérez de Llano Luis26ORCID,Posso Margarita227,Rocha Claudio2,Quirce Santiago28,Sastre Joaquin29ORCID,Shamji Mohamed3031ORCID,Song Yang2,Steiner Corinna2,Schwarze Jurgen32,Alonso‐Coello Pablo25,Palomares Oscar33ORCID,Jutel Marek3435

Affiliation:

1. Faculty of Medicine Transylvania University Brasov Romania

2. Iberoamerican Cochrane Centre Department of Clinical Epidemiology and Public Health Biomedical Research Institute Sant Pau (IIB Sant Pau) Barcelona Spain

3. Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich Davos Switzerland

4. Christine Kühne-Center for Allergy Research and Education Davos Switzerland

5. CIBER de Epidemiología y Salud Pública (CIBERESP) Madrid Spain

6. Personalized Medicine, Asthma and Allergy Humanitas Clinical and Research CenterIRCCS Rozzano Italy

7. Division of Allergy and Immunology University of South Florida Morsani College of Medicine Tampa FL USA

8. School of Medicine University CEU San Pablo Madrid Spain

9. David Geffen School of Medicine at UCLA Los Angeles CA USA

10. Department of Medical Sciences and Public Health University of Cagliari Cagliari Italy

11. Translational Medicine Program Research Institute Hospital for Sick Children Toronto ON Canada

12. Department of Immunology University of Toronto Toronto ON Canada

13. Division of Immunology and Allergy Food Allergy and Anaphylaxis Program The Hospital for Sick Children Departments of Paediatrics and Immunology University of Toronto Toronto Canada

14. Department of Pediatrics University of Wisconsin School of Medicine and Public Health Madison WI USA

15. Klinik für Kinder‐ und Jugendmedizin Kinderzentrum Bethel Bielefeld Germany

16. Section of Pulmonary, Critical Care and Sleep Medicine Baylor College of Medicine Houston TX USA

17. Skin and Allergy Hospital Helsinki University Hospital and University of Helsinki Helsinki Finland

18. Department of Allergy Hospital Universitario La Paz Madrid Spain

19. Division of Respirology Department of Medicine McMaster University Hamilton ON Canada

20. Firestone Institute for Respiratory Health St Joseph's Healthcare Hamilton ON Canada

21. Departments of Medicine and Microbiology APC Microbiome Ireland University College Cork Cork Ireland

22. Division of Infection, Immunity and Respiratory Medicine University of Manchester Manchester UK

23. Allergy Department Second Pediatric Clinic National Kapodistrian University of Athens Athens Greece

24. Research Center on Asthma and COPD Department of Medical Sciences University of Ferrara Ferrara Italy

25. Department of Allergy and Clinical Immunology Ajou University Suwon Korea

26. Department of Respiratory Medicine Hospital Lucus Augusti Lugo Spain

27. Department of Epidemiology and Evaluation IMIM (Hospital del Mar Medical Research Institute) Barcelona Spain

28. Department of Allergy La Paz University Hospital IdiPAZ CIBER of Respiratory Diseases (CIBERES) Universidad Autónoma de Madrid Madrid Spain

29. Universidad Autónoma de Madrid Facultad de Medicina Madrid Spain

30. Immunomodulation and Tolerance Group Allergy and Clinical Immunology, Inflammation, Repair, Development National Heart and Lung Institute London UK

31. Imperial College NIHR Biomedical Research Centre Asthma UK Centre in Allergic Mechanisms of Asthma London UK

32. Centre for Inflammation Research, Child Life and Health The University of Edinburgh Edinburgh UK

33. Department of Biochemistry and Molecular Biology Chemistry School Complutense University of Madrid Madrid Spain

34. Department of Clinical Immunology Wroclaw Medical University Wroclaw Poland

35. All‐MED Medical Research Institute Wroclaw Poland

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

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