Unusual presentation of disseminated cryptococcal infection complicated by myocarditis in a heart transplant recipient-Reference-Cited by-同舟云学术

Unusual presentation of disseminated cryptococcal infection complicated by myocarditis in a heart transplant recipient

Published:2023-07-25 Issue:1 Volume:28 Page:
ISSN:1397-3142
Container-title:Pediatric Transplantation
language:en
Short-container-title:Pediatric Transplantation

Author:

Barros Kathryn¹^ORCID,Tepper John William²,Ramchandani Juhi²^ORCID,Kelley Meagan Kristine²,Kussin Michelle L.³,Israel Emily N.⁴⁵,Tompkins Madeline G.⁶,Alali Muayad¹^ORCID

Affiliation:

1. Ryan White Center for Pediatric Infectious Diseases & Global Health Indiana University Indianapolis Indiana USA

2. Department of Pediatrics Indiana University School of Medicine Indianapolis Indiana USA

3. Pediatric Infectious Diseases, Department of Pharmacy, Riley Hospital for Children at Indiana University Health and Ryan White Center for Pediatric Infectious Diseases & Global Health Indiana University Indianapolis Indiana USA

4. Purdue College of Pharmacy West Lafayette Indiana USA

5. Department of Pharmacy Riley Hospital for Children at Indiana University Health Indianapolis Indiana USA

6. Pediatric Cardiology, Department of Pharmacy Riley Hospital for Children at Indiana University Health Indianapolis Indiana USA

Abstract

AbstractBackgroundCryptococcus neoformans is the third most common cause of invasive fungal infection in solid organ transplant (SOT) recipients. While cryptococcal infection can involve any organ, cases of myocarditis are exceedingly rare.MethodsA retrospective chart review was completed for this case report.ResultsWe present the case of a 21‐year‐old heart transplant recipient who developed disseminated cryptococcal infection with biopsy‐proven cryptococcal myocarditis.ConclusionsCryptococcal disease in SOT recipients poses diagnostic and therapeutic challenges. There are no current guidelines for the duration of cryptococcal myocarditis treatment. Repeat myocardial biopsy may play a role in guiding length of therapy.

Publisher

Wiley

Subject

Transplantation,Pediatrics, Perinatology and Child Health

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/petr.14585

Reference31 articles.

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2. Invasive fungal infections in transplant recipients

3. Cryptococcosis in Solid Organ Transplantation

4. A cluster of donor-derivedCryptococcus neoformansinfection affecting lung, liver, and kidney transplant recipients: Case report and review of literature

5. BlancP HoffmanP MichaelsJ BernardE VintiH.L'atteinte cardiaque des patients porteurs du virus de l'immunosuppression humaine (VIH): à propos de 38 cas. Paper presented at: Annales de cardiologie et d'angéiologie (Paris) 1990.