Early-life regional and temporal variation in filaggrin-derived natural moisturizing factor, filaggrin-processing enzyme activity, corneocyte phenotypes and plasmin activity: implications for atopic dermatitis

Author:

McAleer M.A.12,Jakasa I.3,Raj N.4,O'Donnell C.P.F.5,Lane M.E.4,Rawlings A.V.4,Voegeli R.6,McLean W.H.I.7,Kezic S.8,Irvine A.D.129ORCID

Affiliation:

1. National Children's Research Centre; Our Lady's Children's Hospital; Dublin Ireland

2. Paediatric Dermatology; Our Lady's Children's Hospital; Dublin Ireland

3. Laboratory for Analytical Chemistry; Department of Chemistry and Biochemistry; Faculty of Food Technology and Biotechnology; University of Zagreb; Zagreb Croatia

4. School of Pharmacy; University College London; London U.K

5. Department of Neonatology; National Maternity Hospital; Dublin Ireland

6. DSM Nutritional Products Ltd; Wurmisweg 571 Kaiseraugst Switzerland

7. Dermatology and Genetic Medicine; Division of Biological Chemistry and Drug Discovery; School of Life Sciences; University of Dundee; Dundee U.K

8. Coronel Institute of Occupational Health; Amsterdam Public Health Research Institute; Academic Medical Center; Amsterdam the Netherlands

9. Department of Clinical Medicine; Trinity College Dublin; Dublin Ireland

Funder

National Children's Research Centre, Dublin, Ireland

DSM Ltd

Wellcome Trust

Publisher

Wiley

Subject

Dermatology

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