Islet‐specific CD8 + T cells gain effector function in the gut lymphoid tissues via bystander activation not molecular mimicry
Author:
Affiliation:
1. The University of Queensland Diamantina Institute, The University of Queensland Woolloongabba QLDAustralia
2. Division of Infection and Immunity and Systems Immunity University Research Institute, School of Medicine Cardiff University Cardiff UK
Funder
Juvenile Diabetes Research Foundation International
Fondazione Diabete Ricerca
Children's Hospital Foundation
Publisher
Wiley
Subject
Cell Biology,Immunology,Immunology and Allergy
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1111/imcb.12593
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1. Environmental risk factors for type 1 diabetes
2. Microbiome and type 1 diabetes
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4. Loss of gut barrier integrity triggers activation of islet-reactive T cells and autoimmune diabetes
5. Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes
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