Highly electronegative low-density lipoprotein L5 evokes microglial activation and creates a neuroinflammatory stress via Toll-like receptor 4 signaling

Author:

Yu Liang-En1,Lai Chiou-Lian12,Lee Ching-Tien3,Wang Jiz-Yuh14ORCID

Affiliation:

1. Graduate Institute of Medicine; College of Medicine; Kaohsiung Medical University; Kaohsiung Taiwan

2. Department of Neurology; Kaohsiung Medical University Hospital; Kaohsiung Taiwan

3. Department of Nursing; Hsin-Sheng College of Medical Care and Management; Taoyuan Taiwan

4. Department of Medical Research; Kaohsiung Medical University Hospital; Kaohsiung Taiwan

Funder

Ministry of Science and Technology

Kaohsiung Medical University

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Biochemistry

Reference56 articles.

1. Proteomic analysis of electronegative low-density lipoprotein;Bancells;J. Lipid Res.,2010

2. Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease;Bell;Acta Neuropathol.,2009

3. Pro-inflammatory action of LDL(−) on mononuclear cells is counteracted by increased IL10 production;Benitez;Biochem. Biophys. Acta.,2007

4. The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway;Berra;J. Biol. Chem.,1998

5. Blood-brain barrier disturbance in patients with Alzheimer's disease is related to vascular factors;Blennow;Acta Neurol. Scand.,1990

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