Possible impact of HLA class I and class II on malignancies driven by a single germ‐line BRCA1 mutation-Reference-Cited by-同舟云学术

Possible impact of HLA class I and class II on malignancies driven by a single germ‐line BRCA1 mutation

Published:2023-07-28 Issue:5 Volume:50 Page:243-248
ISSN:1744-3121
Container-title:International Journal of Immunogenetics
language:en
Short-container-title:Int J Immunogenetics

Author:

Ivanova Milena¹^ORCID,Ormandjieva Anastasia¹,Dodova Rumyana²,Kaneva Radka²,Shivarov Velizar³^ORCID

Affiliation:

1. Department of Clinical Immunology University Hospital Alexandrovska, Medical University Sofia Sofia Bulgaria

2. Center for Molecular Medicine Department of Medical Chemistry and Biochemistry Medical Faculty Medical University Sofia Sofia Bulgaria

3. Department of Experimental Research Medical University Pleven Pleven Bulgaria

Abstract

AbstractThis study provides the first immunogenetic preliminary evidence that specific human leucocyte antigen (HLA) class I and class II alleles and haplotypes may be relevant for BRCA1 c.5263_5264insC driven oncogenesis. Observed HLA associations might have practical implications for establishment of predictive markers for the response to immunotherapies in malignancies driven by this germ‐line mutation.

Publisher

Wiley

Subject

Genetics (clinical),Genetics,Molecular Biology,General Medicine,Immunology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/iji.12631

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1. Negative Association of the HLA-DQB1*02 Allele with Breast Cancer Development among Jordanians

2. Breast Cancer Is Associated with Increased HLA-DRB1*11:01 and HLA-DRB1*10:01 Allele Frequency in a Population of Patients from Central Italy

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