Affiliation:
1. Department of Dermatology Nara Medical University School of Medicine Kashihara Japan
2. Department of Dermatology Nara Prefecture General Medical Center Nara Japan
3. Department of Diagnostic Pathology Nara Medical University School of Medicine Kashihara Japan
4. Department of Thoracic and Cardiovascular Surgery Nara Medical University School of Medicine Kashihara Japan
5. Fukumoto Dermatopathology Clinic Nara Japan
Abstract
AbstractThe histopathologic diagnosis of poorly differentiated cutaneous angiosarcoma can be challenging. We report a case of cutaneous epithelioid angiosarcoma with numerous multinucleated giant cells (MGCs) developing pulmonary metastasis. A 79‐year‐old man presented with a red–purple plaque on the scalp. A skin biopsy revealed epithelioid cell proliferation, admixed with numerous MGCs, and background hemorrhage. Vascular spaces were focally present and lined by atypical endothelial cells, including MGCs. Immunohistochemically, tumor cells, including MGCs, were positive for CD31, D2‐40, and ERG. The patient received radiation therapy and chemotherapy, after which a follow‐up CT scan revealed symptomless pneumothorax and pulmonary metastases. The patient received palliative partial lung resection, and the specimen revealed histopathological and immunohistochemical features similar to the primary cutaneous lesion. Our report expands the morphologic spectrum of cutaneous epithelioid angiosarcoma. Cutaneous angiosarcoma is an aggressive neoplasm; thus, awareness of this rare manifestation is important.