Pharmacokinetics and pharmacodynamics of liposomal mifamurtide in adult volunteers with mild or moderate hepatic impairment

Author:

Venkatakrishnan Karthik1,Liu Yi2,Noe Dennis1,Mertz Jaime1,Bargfrede Michael1,Marbury Thomas3,Farbakhsh Kambiz4,Oliva Cristina5,Milton Ashley1

Affiliation:

1. Clinical Pharmacology; Takeda Pharmaceuticals International Company; Cambridge MA USA

2. Biostatistics; Takeda Pharmaceuticals International Company; Cambridge MA USA

3. Orlando Clinical Research Centre; Orlando FL USA

4. DaVita Clinical Research; Phase 1; Minneapolis MN USA

5. Clinical Research; Takeda Global Research and Development Europe; London UK

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference21 articles.

1. Mifamurtide: a review of its use in the treatment of osteosarcoma;Frampton;Paediatr Drugs,2010

2. Activation of tumoricidal properties in human blood monocytes by liposomes containing lipophilic muramyl tripeptide;Kleinerman;Cancer Res,1983

3. Activation of tumoricidal properties in monocytes from cancer patients following intravenous administration of liposomes containing muramyl tripeptide phosphatidylethanolamine;Kleinerman;Cancer Res,1989

4. Muramyl tripeptide (mifamurtide) for the treatment of osteosarcoma;Meyers;Expert Rev Anticancer Ther,2009

5. Induction of Nod2 in myelomonocytic and intestinal epithelial cells via nuclear factor-kappa B activation;Gutierrez;J Biol Chem,2002

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