Affiliation:
1. Institute for Genetic Medicine, Hokkaido University Sapporo Japan
2. Institute of Microbial Chemistry (BIKAKEN) Shinagawa‐ku Japan
Abstract
AbstractAutophagy is a lysosomal degradation system of cytoplasmic components that contributes to cellular homeostasis through the turnover of various biomolecules and organelles, often in a selective manner. Autophagy is closely related to cancer, but its roles in cancer are complicated. It works as either a promoter or suppressor, depending on the stage and type of cancer. In this review, we briefly summarize the basic mechanisms of autophagy and describe the complicated roles of autophagy in cancer. Moreover, we summarize the clinical trials of autophagy inhibitors targeting cancer and the development of more specific autophagy inhibitors for future clinical application.
Funder
Core Research for Evolutional Science and Technology
Japan Society for the Promotion of Science
Takeda Science Foundation
Subject
Cancer Research,Oncology,General Medicine
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献