Affiliation:
1. Department of Psychiatry Renmin Hospital of Wuhan University Wuhan Hubei China
2. Department of Psychiatry McGill University Montreal Quebec Canada
3. McGill Group for Suicide Studies, Douglas Mental Health University Institute McGill University Montreal Quebec Canada
4. Taikang Center for Life and Medical Sciences Wuhan University Wuhan China
Abstract
AimThe current study aimed to investigate the neuroinflammatory hypothesis of depression and the potential anti‐inflammatory effect of electroconvulsive therapy (ECT) in vivo, utilizing astrocyte‐derived extracellular vesicles (ADEVs) isolated from plasma.MethodsA total of 40 patients with treatment‐resistant depression (TRD) and 35 matched healthy controls were recruited at baseline, and 34 patients with TRD completed the post‐ECT visits. Blood samples were collected at baseline and post‐ECT. Plasma ADEVs were isolated and confirmed, and the concentrations of two astrocyte markers (glial fibrillary acidic protein [GFAP] and S100β), an extracellular vesicle marker cluster of differentiation 81 (CD81), and nine inflammatory markers in ADEVs were measured as main analyses. In addition, correlation analysis was conducted between clinical features and ADEV protein levels as exploratory analysis.ResultsAt baseline, the TRD group exhibited significantly higher levels of two astrocyte markers GFAP and S100β, as well as CD81 compared with the healthy controls. Inflammatory markers interferon γ (IFN‐γ), interleukin (IL) 1β, IL‐4, IL‐6, tumor necrosis factor α, IL‐10, and IL‐17A were also significantly higher in the TRD group. After ECT, there was a significant reduction in the levels of GFAP, S100β, and CD81, along with a significant decrease in the levels of IFN‐γ and IL‐4. Furthermore, higher levels of GFAP, S100β, CD81, and inflammatory cytokines were associated with more severe depressive symptoms and poorer cognitive function.ConclusionThis study provides direct insight supporting the astrocyte activation and neuroinflammatory hypothesis of depression using ADEVs. ECT may exert an anti‐inflammatory effect through inhibition of such activation of astrocytes.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Subject
Psychiatry and Mental health,Neurology (clinical),Neurology,General Medicine,General Neuroscience
Cited by
2 articles.
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