Clinical pharmacology of single- and multiple-ascending doses of ACT-178882, a new direct renin inhibitor, and its pharmacokinetic interaction with food and midazolam-Reference-Cited by-同舟云学术

Clinical pharmacology of single- and multiple-ascending doses of ACT-178882, a new direct renin inhibitor, and its pharmacokinetic interaction with food and midazolam

Published:2012-07-31 Issue:6 Volume:27 Page:698-710
ISSN:0767-3981
Container-title:Fundamental & Clinical Pharmacology
language:en
Short-container-title:Fundam Clin Pharmacol

Author:

Dingemanse Jasper¹,Nicolas Laurent¹,Binkert Christoph²

Affiliation:

1. Department of Clinical Pharmacology; Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123; Allschwil Switzerland

2. Department of Drug Discovery Biology; Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123; Allschwil Switzerland

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1472-8206.2012.01060.x/fullpdf

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4. Renal and hormonal responses to direct renin inhibition with aliskiren in healthy humans;Fisher;Circulation,2008

5. Blocking the RAAS at different levels: an update on the use of the direct renin inhibitors alone and in combination;Cagnoni;Vasc. Health Risk Manag.,2010

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3. Investigation of combined CYP3A4 inductive/inhibitory properties by studying statin interactions: a model study with the renin inhibitor ACT-178882;European Journal of Clinical Pharmacology;2014-04-15

4. Age and Sex Effects on the Single- and Multiple-dose Safety and Pharmacokinetics of the New Rennin Inhibitor ACT-178882;Cardiovascular Therapeutics;2013-11-27

5. Drug-Drug Interaction Study of ACT-178882, a New Renin Inhibitor, and Diltiazem in Healthy Subjects;Clinical Drug Investigation;2013-02-05