Potential impact of ADAM‐10 genetic variants with the clinical features of oral squamous cell carcinoma

Abstract

AbstractA disintegrin and metalloproteinase domain‐containing protein 10 (ADAM‐10) involves in the tumour progression, but the impacts of single‐nucleotide polymorphism (SNP) of ADAM‐10 on oral squamous cell carcinoma (OSCC) remain unclear. The aim of this study was to investigate the influence of SNP of ADAM‐10 on the clinical features of OSCC in male Taiwanese. Five loci of ADAM‐10 SNPs including rs653765 (C/T), rs2305421 (A/G), rs514049 (A/C), rs383902 (T/C) and rs2054096 (A/T) were genotyped by TaqMan allelic discrimination in 1138 OSCC patients and 1199 non‐OSCC individuals. The ADAM‐10 SNP rs2305421 GG (AOR: 1.399, 95% CI: 1.045–1.874, p = 0.024) and G allele (AOR: 1.170, 95% CI: 1.012–1.351, p = 0.034) illustrated a significantly higher genotypic frequencies in the OSCC group compared to the distribution of the ADAM‐10 SNP rs2305421 AA wild type. In the subgroup analysis, the ADAM‐10 SNP rs383902 TC+CC was significantly correlated to tumour size larger than T2 in betel quid chewer (AOR: 1.375, 95% CI: 1.010–1.872, p = 0.043), while the ADAM‐10 SNP rs653765 CT+TT was significantly associated with tumour size larger than T2 in cigarette smoker (AOR: 1.346, 95% CI: 1.023–1.772, p = 0.034). The results from The Cancer Genome Atlas revealed highest ADAM‐10 mRNA level in T2 stage of current smokers with head and neck squamous cell carcinoma (HNSCC). In conclusions, the ADAM‐10 SNP rs2305421 G allele is associated with the presence of OSCC, and the ADAM‐10 SNP rs383902 TC+CC and ADAM‐10 SNP rs653765 CT+TT correlates to large tumour size in specific conditions.