The Circ_35953 induced by the NF‐κB mediated the septic AKI via targeting miR‐7219‐5p/HOOK3 and IGFBP7 axis

Abstract

AbstractA few studies suggested that CircRNAs were involved in the development of septic AKI. However，the role and regulation mechanism of CircRNA_35953 in septic AKI remains unclear. Here, we found that Circ_35953 was induced by LPS via activation of NF‐κB signal in BUMPT cells. Functionally, Circ_35953 mediated the LPS induced the apoptosis in BUMPT cells. Moreover, we demonstrated that Circ_35953 sponged miR‐7219‐5p to upregulate the expression of HOOK3 and IGFBP7. Finally, we verified that knock down of Circ_35953 alleviated the progression of CLP‐induced AKI via targeting the miR‐7219‐5p/HOOK3 and IGFBP7 signal. Collectively, the data suggested that Circ_35953 /miR‐7219‐5p/HOOK3 and IGFBP7 axis mediated the septic AKI, which also revealed a potential mechanism of septic AKI.