Efficacy and safety of treatment with biologicals for severe chronic rhinosinusitis with nasal polyps: A systematic review for the EAACI guidelines

Author:

Agache Ioana1ORCID,Song Yang2,Alonso‐Coello Pablo23,Vogel Yasmin4,Rocha Claudio2,Solà Ivan2,Santero Marilina2,Akdis Cezmi A.56ORCID,Akdis Mubeccel5ORCID,Canonica Giorgio Walter7,Chivato Tomas8,Giacco Stefano9ORCID,Eiwegger Thomas101112ORCID,Fokkens Wytske13ORCID,Georgalas Christos14,Gevaert Philippe15,Hopkins Claire16,Klimek Ludger17,Lund Valerie18,Naclerio Robert19,O'Mahony Liam20ORCID,Palkonen Susanna21,Pfaar Oliver22ORCID,Schwarze Jürgen23,Soyka Michael B.24,Wang De Yun25ORCID,Zhang Luo262728,Canelo‐Aybar Carlos23,Palomares Oscar29ORCID,Jutel Marek3031

Affiliation:

1. Transylvania University Brasov Brasov Romania

2. Department of Clinical Epidemiology and Public Health Iberoamerican Cochrane Centre Biomedical Research Institute Sant Pau (IIB Sant Pau) Barcelona Spain

3. CIBER de Epidemiología y Salud Pública (CIBERESP) Madrid Spain

4. Furtwangen University Furtwangen im Schwarzwald Germany

5. Swiss Institute of Allergy and Asthma Research (SIAF) University of Zurich Davos Switzerland

6. Christine Kühne‐Center for Allergy Research and Education Davos Switzerland

7. Personalized Medicine Asthma & Allergy Clinic IRCCS Research Hospital Humanitas University Milan Italy

8. School of Medicine University CEU San Pablo Madrid Spain

9. Department of Medical Sciences and Public Health University of Cagliari Cagliari Italy

10. Translational Medicine Program Research Institute Hospital for Sick Children Toronto ON Canada

11. Department of Immunology University of Toronto Toronto ON Canada

12. Division of Immunology and Allergy Food Allergy and Anaphylaxis Program Departments of Paediatrics and Immunology The Hospital for Sick Children University of Toronto Toronto ON Canada

13. Department of Otorhinolaryngology Academic Medical Center (AMC) University of Amsterdam Amsterdam The Netherlands

14. Medical School University of Nicosia Nicosia Cyprus

15. Department of Otorhinolaryngology Upper Airway Research Laboratory (URL) Ghent University Hospital Ghent Belgium

16. Department of ENT Guy's Hospital London UK

17. Zentrum für Rhinologie und Allergologie Wiesbaden Germany

18. Royal National Throat, Nose and Ear Hospital UCLH London UK

19. Department of Otolaryngology ‐ Head and Neck Surgery Johns Hopkins University Baltimore MD USA

20. Departments of Medicine and Microbiology APC Microbiome Ireland University College Cork Cork Ireland

21. European Federation of Allergy and Airways Diseases Patients' Associations (EFA) Brussels Belgium

22. Department of Otorhinolaryngology, Head and Neck Surgery Section of Rhinology and Allergy University Hospital Marburg Philipps‐Universität Marburg Marburg Germany

23. Centre for Inflammation Research, Child Life and Health The University of Edinburgh Edinburgh UK

24. Department of Otorhinolaryngology, Head and Neck Surgery University Hospital Zurich University of Zurich Zurich Switzerland

25. Department of Otolaryngology Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore

26. Department of Otolaryngology–Head and Neck Surgery Beijing TongRen Hospital Capital Medical University Beijing China

27. Department of Allergy Beijing TongRen Hospital Capital Medical University Beijing China

28. Beijing Key Laboratory of Nasal Diseases Beijing Institute of Otolaryngology Beijing China

29. Department of Biochemistry and Molecular Biology Chemistry School Complutense University of Madrid Madrid Spain

30. Department of Clinical Immunology University of Wroclaw Wroclaw Poland

31. “ALL‐MED” Medical Research Institute Wroclaw Poland

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference58 articles.

1. European position paper on rhinosinusitis and nasal polyps 2020;Fokkens WJ;Rhinology,2020

2. Adult chronic rhinosinusitis

3. Chronic rhinosinusitis with nasal polyps impact in severe asthma patients: Evidences from the Severe Asthma Network Italy (SANI) registry

4. Medical algorithm: Diagnosis and treatment of chronic rhinosinusitis

5. Direct and indirect costs of adult patients with chronic rhinosinusitis with nasal polyps;Lourijsen ES;Rhinology,2020

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