Author:
FREEMAN J.J.,KOSH J.W.,PARRISH J.S.
Abstract
The site (i.e. peripheral or central) of the toxicity produced by hemicholinium‐3 in mice was investigated.
Hemicholinium‐3 was measured fluorometrically and acetylcholine was determined by gas chromatography after intraventricular or intraperitoneal administration of hemicholinium‐3.
Hemicholinium‐3 was not detected in the brain nor were acetylcholine levels decreased in the brain after systemic administration.
The dose‐response curve following intraventricular administration demonstrated that hemicholinium‐3 was not as lethal after central administration as it was after peripheral administration.
Approximately 24% of a 75 μg intraventricular dose of hemicholinium‐3 was found in the periphery at death.
These results suggest that hemicholinium‐3 manifests its toxicity primarily in the periphery.
Reference35 articles.
1. Respiratory depressant effect of HC‐3;Borison H.L.;Fedn. Proc.,1961
2. Atropine-like properties of hemicholinium-3
3. Effect of ethanol, pentobarbital, and morphine on the toxicity of hemicholinium‐3 and d‐tubocurarine in mice;Clement J.G.;Archs. Int. Pharmacodyn. Thér.,1978
4. The source of choline for acetylcholine synthesis in a sympathetic ganglion
Cited by
10 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献