Matrix metalloproteinase‐13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha‐1 antitrypsin: Implications for osteoarthritis

Author:

Wilkinson David J.12ORCID,Falconer Adrian M. D.2,Wright Helen L.1,Lin Hua2,Yamamoto Kazuhiro1,Cheung Kathleen2,Charlton Sarah H.2,Arques Maria del Carmen2,Janciauskiene Sabina3,Refaie Ramsay2,Rankin Kenneth S.4ORCID,Young David A.2,Rowan Andrew D.2

Affiliation:

1. Institute of Life Course and Medical Sciences University of Liverpool UK

2. Skeletal Research Group Institute of Genetic Medicine Newcastle University UK

3. Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH) Department of Respiratory Medicine Deutsches Zentrum für Lungenforschung Hannover Medical School Germany

4. Translational and Clinical Research Institute Newcastle Centre for Cancer UK

Funder

JGW Patterson Foundation

NIHR Newcastle Biomedical Research Centre

Versus Arthritis

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

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