Affiliation:
1. American Academy of Epidemiology, Inc. Tyler Texas USA
2. Department of Epidemiology University of Colorado School of Public Health, Anschutz Medical Campus Aurora Colorado USA
3. Public Health Strategies, LLC South Charleston West Virginia USA
4. Vanderbilt Institute for Clinical and Translational Research Vanderbilt University Medical Center Nashville Tennessee USA
5. Cancer Center Renmin Hospital of Wuhan University Wuhan City Hubei Province P.R. China
6. Section of Endocrinology and Metabolism Wake Forest School of Medicine Winston‐Salem North Carolina USA
7. Division of Epidemiology, Department of Medicine Vanderbilt University Medical Center Nashville Tennessee USA
Abstract
AbstractAimsTo determine the relationship of diabetes with pancreatic cancer incidence among African American and Whites of similar socio‐economic status.MethodsUsing the Southern Community Cohort Study, we conducted a follow‐up during 2002–2015 of pancreatic cancer incidence of 73,378 mostly low‐income participants aged 40–79 years; 15,913 reported diabetes at baseline. Multivariable Cox analysis controlling for sex, family history of pancreatic cancer, BMI, smoking status, alcohol consumption, education, income and other important covariates, and with age as the timescale was used.ResultsTotally, 265 incident pancreatic cancer cases were observed. Pancreatic cancer risk was increased among those with diabetes (HR 1.54, CI 1.16–2.05), with similar increases among African Americans (HR 1.51, CI 1.08–2.11) and Whites (HR 1.78, CI 1.00–3.16). No trend in risk was observed for diabetes duration among those with diabetes, with HRs of 1.39 (0.91–2.11), 2.31 (1.51–3.54) and 1.23 (0.80–1.89) for <5, 5–9 and 10+ years duration, respectively. African Americans were at increased risk of pancreatic cancer (HR = 1.40, 95% CI 1.05–1.87), which persisted after adjusting for diabetes (HR 1.36, CI 1.02–1.81). The effect sizes for other pancreatic cancer risk factors with pancreatic cancer were similar by diabetes status, although a stronger association with low BMI was evident among those with diabetes.ConclusionsDiabetes increases pancreatic cancer risk similarly among African Americans and Whites in this Southern U.S. cohort.
Funder
National Institutes of Health
Subject
Endocrinology,Endocrinology, Diabetes and Metabolism,Internal Medicine
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