Decreased spermatogonial numbers in boys with severe haematological diseases-Reference-Cited by-同舟云学术

Decreased spermatogonial numbers in boys with severe haematological diseases

Published:2024-05-29 Issue:1 Volume:205 Page:229-235
ISSN:0007-1048
Container-title:British Journal of Haematology
language:en
Short-container-title:Br J Haematol

Author:

Lahtinen Atte K.¹²^ORCID,Funke Miriam³,Krallmann Claudia⁴,Wyrwoll Margot J.⁴,Jarisch Andrea⁵,Yang Yifan⁶,Bjarnason Ragnar⁷⁸,Romerius Patrik⁹,Sundin Mikael¹⁰¹¹,Norén‐Nyström Ulrika¹²,Langenskiöld Cecilia¹³,Cremers Jann‐Frederik⁴,Kliesch Sabine⁴,Stukenborg Jan‐Bernd⁶,Neuhaus Nina³,Jahnukainen Kirsi⁶¹⁴

Affiliation:

1. Applied Tumor Genomics Research Program, Faculty of Medicine University of Helsinki Helsinki Finland

2. Department of Medical and Clinical Genetics/Medicum, Faculty of Medicine University of Helsinki Helsinki Finland

3. Centre of Reproductive Medicine and Andrology Institute of Reproductive and Regenerative Biology, University Münster Munster Germany

4. Department of Clinical and Surgical Andrology, Centre of Reproductive Medicine and Andrology University Hospital Münster Munster Germany

5. Division of Stem Cell Transplantation and Immunology, Department of Children and Adolescent Medicine University Hospital Frankfurt, Johann Wolfgang Goethe University Frankfurt am Main Germany

6. NORDFERTIL Research Lab Stockholm, Department of Women's and Children's Health, Karolinska Institutet and Karolinska University Hospital Stockholm Sweden

7. Children's Medical Center Landspítali University Hospital Reykjavik Iceland

8. Department of Paediatrics, Faculty of Medicine University of Iceland Reykjavik Iceland

9. Department of Paediatric Oncology and Haematology, Clinical Sciences Lund University, Barn‐Och Ungdomssjukhuset Lund, Skånes Universitetssjukhus Lund Sweden

10. Division of Paediatrics, Department of Clinical Science, Intervention and Technology Karolinska Institutet Stockholm Sweden

11. Section of Paediatric Haematology, Immunology and HCT, Astrid Lindgren Children's Hospital Karolinska University Hospital Stockholm Sweden

12. Division of Paediatrics, Department of Clinical Science Umeå University Umeå Sweden

13. Department of Paediatric Oncology The Queen Silvia Children's Hospital Gothenburg Sweden

14. New Children's Hospital, Pediatric Research Center University of Helsinki and Helsinki University Hospital Helsinki Finland

Abstract

SummaryThis study examines spermatogonial numbers in testicular samples from 43 prepubertal patients undergoing haematopoietic stem cell transplantation (HSCT). High‐dose chemotherapy and/or radiation during HSCT can impact spermatogenesis requiring fertility preservation. Results show that 49% of patients have decreased and 19% severely depleted spermatogonial pool prior to HSCT. Patients with Fanconi anaemia exhibit significantly reduced spermatogonial numbers. Patients with immunodeficiency or aplastic anaemia generally present within the normal range, while results in patients with myelodysplastic syndrome or myeloproliferative neoplasm vary. The study emphasizes the importance of assessing spermatogonial numbers in patients with severe haematological diseases for informed fertility preservation decisions.

Funder

Suomalais-Norjalainen Lääketieteen Säätiö

Deutsche Forschungsgemeinschaft

Biomedicum Helsinki-säätiö

Vetenskapsrådet

Syöpäsäätiö

Suomen Lääketieteen Säätiö

Lastentautien Tutkimussäätiö

Orionin Tutkimussäätiö

Juhani Ahon Lääketieteen Tutkimussäätiö

Barncancerfonden

Westfälische Wilhelms-Universität Münster