Icariin induces osteogenic differentiation of bone mesenchymal stem cells in a MAPK-dependent manner

Author:

Wu Yuqiong12,Xia Lunguo3,Zhou Yuning4,Xu Yuanjin14,Jiang Xinquan12

Affiliation:

1. Department of Prosthodontics; Ninth People's Hospital; Shanghai Jiao Tong University School of Medicine; Shanghai 200011 China

2. Oral Bioengineering and Regenerative Medicine Lab; Shanghai Research Institute of Stomatology; Ninth People's Hospital; Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Stomatology; Shanghai 200011 China

3. Center of Craniofacial Orthodontics; Department of Oral and Cranio-maxillofacial Science; Ninth People's Hospital; Shanghai Jiao Tong University School of Medicine; Shanghai 200011 China

4. Department of Oral Surgery; Ninth People's Hospital; College of Stomatology; Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology; Shanghai 200011 China

Funder

Shanghai Science and Technology Development Fund

Biomedical Engineering Cross Research Foundation of Shanghai Jiao Tong University School

Specialized Research Fund for the Doctoral Program of Higher Education

Publisher

Wiley

Subject

Cell Biology,General Medicine

Reference44 articles.

1. Interactions between modern and Chinese medicinal drugs: a general review;Cheng;Am. J. Chin. Med.,2003

2. Determination of flavonoids and quality evaluation of Sagittate Epimedium (Epimedium sagittatum);Guo;China Trad. Herb Drugs,1996

3. Antiosteoporotic activity of icariin in ovariectomized rats;Nan;Phytomedicine,2009

4. Icariin protects against bone loss induced by oestrogen deficiency and activates oestrogen receptor-dependent osteoblastic functions in UMR 106 cells;Mok;Br. J. Pharmacol.,2010

5. Icariin, a flavonoid from the herb Epimedium enhances the osteogenic differentiation of rat primary bone marrow stromal cells;Chen;Pharmazie,2005

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