Isolation, structure determination and synthesis of a novel tryptophan‐containing heptapeptide (basic tryptophyllin) from the skin of Phyllomedusa rohdei

Abstract

A novel tryptophyllin has been isolated from the methanol extracts of the skin of the South American frog Phyllomedusa rohdei. Its primary structure, as determined by chemical/enzymatic methods and by FAB mass spectrometry, is the following: Lys‐Pro‐Hyp‐Ser‐Trp‐Ile‐Pro‐NH2. This basic tryptophyllin has been synthesized in solid phase, in order to allow its complete pharmacological characterization.