Variant <scp>ALK</scp>‐fusion positive anaplastic large cell lymphoma (<scp>ALCL</scp>): A population‐based paediatric study of the <scp>NHL‐BFM</scp> study group-Reference-Cited by-同舟云学术

Variant ALK‐fusion positive anaplastic large cell lymphoma (ALCL): A population‐based paediatric study of the NHL‐BFM study group

Published:2024-01-26 Issue: Volume: Page:
ISSN:0007-1048
Container-title:British Journal of Haematology
language:en
Short-container-title:Br J Haematol

Author:

Luedersen Jette¹,Stadt Udo zur²,Richter Julia³^ORCID,Oschlies Ilske³,Klapper Wolfram³^ORCID,Rosenwald Andreas⁴,Kalinova Marketa⁵⁶,Simonitsch‐Klupp Ingrid⁷,Siebert Reiner⁸,Zimmermann Martin⁹,Qi Minyue¹⁰,Nakel Jacqueline¹¹,Scheinemann Katrin¹²¹³¹⁴,Knörr Fabian¹¹⁵,Attarbaschi Andishe¹⁶¹⁷^ORCID,Kabickova Edita¹⁸,Woessmann Wilhelm¹^ORCID,Damm‐Welk Christine¹^ORCID

Affiliation:

1. Paediatric Haematology and Oncology and NHL‐BFM Study Centre University Medical Centre Hamburg‐Eppendorf Hamburg Germany

2. Paediatric Haematology and Oncology and CoALL Study Centre University Medical Centre Hamburg‐Eppendorf Hamburg Germany

3. Department of Pathology, Haematopathology Section and Lymph Node Registry University Hospital Schleswig‐Holstein Kiel Germany

4. Department of Pathology University of Wuerzburg Wuerzburg Germany

5. Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine Charles University Prague and University Hospital in Motol Prague Czech Republic

6. Department of Pathology, 3rd Faculty of Medicine Charles University Prague and University Hospital Kralovske Vinohrady Prague Czech Republic

7. Department of Pathology Medical University of Vienna Vienna Austria

8. Institute of Human Genetics Ulm University & Ulm University Medical Centre Ulm Germany

9. Department of Paediatric Haematology and Oncology Hannover Medical School, and NHL‐BFM Study Centre Hannover Germany

10. Bioinformatics Core University Medical Centre Hamburg‐Eppendorf Hamburg Germany

11. Leibniz Institute of Virology (LIV) Hamburg Germany

12. Division of Paediatric Haematology/Oncology Children's Hospital of Eastern Switzerland St. Gallen Switzerland

13. Faculty of Health Science and Medicine University of Lucerne Lucerne Switzerland

14. Department of Paediatrics McMaster Children's Hospital and McMaster University Hamilton Ontario Canada

15. Mildred Scheel Cancer Career Centre HaTriCS4 University Medical Centre Hamburg‐ Eppendorf Hamburg Germany

16. Department of Paediatric Haematology and Oncology St. Anna Children's Hospital, Medical University of Vienna Vienna Austria

17. St. Anna Children's Cancer Research Institute Vienna Austria

18. Department of Pediatric Hematology and Oncology Charles University Prague and University Hospital Motol Prague Czech Republic

Abstract

SummaryFrequency, distribution and prognostic meaning of ALK‐partner genes other than NPM1 in ALK‐positive anaplastic large‐cell lymphoma (ALCL) are unknown. Forty‐nine of 316 ALCL diagnosed in the NHL‐BFM study group showed no nuclear ALK expression suggestive of a variant ALK‐partner; 41 were analysed by genomic capture high‐throughput sequencing or specific RT‐PCRs. NPM1::ALK was detected in 13 cases. Among the 28 patients with a non‐NPM1::ALK‐fusion partner, ATIC (n = 8; 29%) and TPM3 (n = 9; 32%) were the most common. Five of eight patients with ATIC::ALK‐positive ALCL relapsed, none of nine with TPM3::ALK. Variant ALK‐partners are rare and potentially associated with different prognoses.

Funder

Deutsche Kinderkrebsstiftung

Publisher

Wiley

Subject

Hematology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjh.19308

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