Development of aprepitant, the first neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting

Author:

Hargreaves Richard,Ferreira Juan Camilo Arjona,Hughes David,Brands Jos,Hale Jeff,Mattson Britta,Mills Sandy

Publisher

Wiley

Subject

History and Philosophy of Science,General Biochemistry, Genetics and Molecular Biology,General Neuroscience

Reference31 articles.

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2. The distribution of substance P and 5-hydroxytryptamine in the central nervous system of the dog;Amin;J. Physiol. (Lond.),1954

3. Amino acid sequence of substance P;Chang;Nat. New Biol.,1971

4. Synthesis of substance P;Tregear;Nat. New Biol.,1971

5. Differential activation of intracellular effector by two isoforms of human neurokinin-1 receptor;Fong;Mol. Pharm.,1992

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