Affiliation:
1. Department of Critical Care Medicine The Third Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong China
2. Guangdong Provincial Key Laboratory of Major Obstetric Diseases Guangzhou China
3. Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology Guangzhou China
4. Department of Respiratory Guangzhou Chest Hospital Guangzhou China
Abstract
AbstractBackgroundTo explore the relationship of peroxiredoxin6 (PRDX6) tag‐single nucleotide polymorphisms (SNPs) with susceptibility to chronic obstructive pulmonary disease (COPD) in the Chinese Han population.MethodsA total of 502 patients with COPD and 481 healthy controls from nine hospitals in China were enrolled in this study. The PRDX6 tag‐SNPs were identified by linkage disequilibrium (LD) analysis in 30 healthy controls. The associations between identified tag‐SNPs and COPD risk were further evaluated.ResultsFour PRDX6 tag‐SNPs, including rs7314, rs34619706, rs33951697, and rs4382766, were identified in 30 healthy controls. Moreover, in the allele model, there was no statistical difference in locus in PRDX6 between patients with COPD and healthy controls (P > 0.05). However, in the recessive model, rs33951697 locus in PRDX6 gene carrier with T/T had an increased risk of COPD (odds ratio [OR] = 2.59, 95% CI = 1.06–6.33, P = 0.028). Furthermore, in the relevance analysis between genetic polymorphisms and smoking behavior and lung function indexes, we found that the number of smoked cigarettes per day and FEV1/FVC differed among different genotypes of PRDX6, rs4382766, and rs7314 (P < 0.05).ConclusionPRDX6 gene polymorphism with smoking status may contribute to the etiology of COPD in the Chinese Han population.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Guangdong Province
Subject
Genetics (clinical),Pulmonary and Respiratory Medicine,Immunology and Allergy