Tetraspanin 1 regulates papillary thyroid tumor growth and metastasis through c‐Myc‐mediated glycolysis

Author:

Han Jihua1,Xie Changming2,Liu Bo1,Wang Yan3,Pang Rui1,Bi Wen1,Sheng Rinan1,He Guoqing1,Kong Lingyu1,Yu Jiawei1,Ding Zhaoming1,Chen Lili1,Jia Jinliang1,Zhang Jiewu1ORCID,Nie Chunlei1

Affiliation:

1. Department of Head and Neck Surgery Harbin Medical University Cancer Hospital Harbin China

2. Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Department of General Surgery The First Affiliated Hospital of Harbin Medical University Harbin China

3. Department of Colorectal Surgery Harbin Medical University Cancer Hospital Harbin China

Abstract

AbstractPapillary thyroid cancer (PTC) is the most common form of thyroid cancer and is characterized by its tendency for lymphatic metastasis, leading to a poor prognosis. Tetraspanin 1 (TSPAN1) is a member of the tetra‐transmembrane protein superfamily and has been implicated in tumorigenesis and cancer metastasis in various studies. However, the role of TSPAN1 in PTC tumor development remains unclear. In this study, we aimed to investigate the impact of TSPAN1 on PTC cell behavior. Our results demonstrate that knockdown of TSPAN1 inhibits PTC cell proliferation, migration, and invasion, while overexpression of TSPAN1 has the opposite effect. These findings suggest that TSPAN1 might play a role in the tumorigenesis and invasiveness of PTC. Mechanistically, we found that TSPAN1 activates the ERK pathway by increasing its phosphorylation, subsequently leading to upregulated expression of c‐Myc. Additionally, we observed that TSPAN1‐ERK‐c‐Myc axis activation promotes glycolytic activity in PTC cells, as evidenced by the upregulation of glycolytic genes such as LDHA. Taken together, our findings indicate that TSPAN1 acts as an oncogene in PTC by regulating glycolytic metabolism. This discovery highlights the potential of TSPAN1 as a promising therapeutic target for PTC treatment. Further research in this area could provide valuable insights into the development of targeted therapies for PTC patients.

Funder

Postdoctoral Research Foundation of China

Publisher

Wiley

Subject

Cancer Research,Oncology,General Medicine

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