Myeloid‐derived suppressor cells as a potential biomarker for recurrent pregnancy loss and recurrent implantation failure

Author:

Marin Nabil Subhi‐Issa12ORCID,Fuente‐Muñoz Eduardo de la1,Gil‐Laborda Raquel1,Villegas Ángela1,Alonso‐Arenilla Bárbara1,Cristóbal Ignacio3,Pilar‐Suárez Lydia3,Jiménez‐Huete Adolfo4,Calvo Marta3,Sarria Beatriz5,Mansilla‐Ruiz Mariló1,Ochoa Juliana1,Fernández‐Arquero Miguel12,Sánchez‐Ramón Silvia12

Affiliation:

1. Department of Immunology IML and IdISSC Hospital Clínico San Carlos Madrid Spain

2. Department of Immunology Ophthalmology, and ENT School of Medicine Complutense University School of Medicine Madrid Spain

3. Department of Obstetrics and Gynecology Hospital Clínico San Carlos Madrid Spain

4. Department of Neurology Clínica Universidad Navarra Madrid Spain

5. Department of Metabolism and Nutrition Institute of Food Science Technology and Nutrition (ICTAN) Spanish National Research Council (CSIC) Madrid Spain

Abstract

AbstractProblemRecurrent pregnancy loss (RPL) and recurrent implantation failure (RIF) represent distinct clinical conditions with established definitions, both of which have been linked to an underlying pro‐inflammatory state. This study aimed to explore the levels of monocytic‐myeloid‐derived suppressor cells (M‐MDSCs) and regulatory T cells (TReg) in a cohort of RPL and RIF women and their potential contribution to RPL and RIF.Method of studyOne hundred and eight non‐pregnant women were evaluated: 40 RPL, 41 RIF, and 27 fertile healthy controls (HC). A multiparametric flow cytometry approach was utilized to measure and quantify the frequency of M‐MDSCs and TReg cells. Cytokine levels in plasma samples were evaluated through a multiplex assay. M‐MDSCs levels were significantly higher in RPL and RIF patients compared to HC.ResultsM‐MDSCs levels were significantly higher in RPL (9.4% [7–11.6]) and RIF (8.1% [5.9–11.6]) patients compared to HC (6% [4.2–7.6]). An optimal cut‐off of 6.1% for M‐MDSCs disclosed a sensitivity of 75.6% and 89.7% and a specificity of 57.7% and 57.7% in RIF and RPL groups, respectively. A significant negative correlation was observed between M‐MDSCs and TReg (p = .002, r = −.51).ConclusionsOur preliminary data allowed us to build a predictive model that may aid as a potential diagnostic tool in the clinic. These findings could provide a better understanding of these pathologies and a better definition of patients that could benefit from personalized treatments to promote pregnancy. Additional exploration and confirmation in distinct study groups are needed to fully assess the diagnostic capabilities of this biomarker.

Publisher

Wiley

Subject

Obstetrics and Gynecology,Reproductive Medicine,Immunology,Immunology and Allergy,Obstetrics and Gynecology,Immunology

Reference52 articles.

1. Guideline of the European Society of Human Reproduction and Embryology;Embryology ES of HR and recurrent pregnancy loss;Eur Soc Hum Reprod Embryol,2017

2. ESHRE good practice recommendations on recurrent implantation failure

3. Recurrent implantation failure: reality or a statistical mirage?

4. Evaluation and treatment of recurrent pregnancy loss: a committee opinion

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3