Mesenchymal stem cell deficiency influences megakaryocytopoiesis through the TNFAIP3/NF-κB/SMAD pathway in patients with immune thrombocytopenia

Author:

He Yun123,Xu Lin-Lin1,Feng Fei-Er1,Wang Qian-Ming1,Zhu Xiao-Lu1,Wang Chen-Cong1,Zhang Jia-Min1,Fu Hai-Xia1,Xu Lan-Ping123,Liu Kai-Yan123,Huang Xiao-Jun123,Zhang Xiao-Hui123ORCID

Affiliation:

1. Peking University People's Hospital, Peking University Institute of Haematology; Beijing China

2. Beijing Key Laboratory of Haematopoietic Stem Cell Transplantation; Beijing China

3. Collaborative Innovation Centre of Haematology; Peking University; Beijing China

Funder

National Natural Science Foundation of China

Natural Science Foundation of Beijing Municipality

Beijing Municipal Science and Technology Commission

National Key Research and Development Program of China

Publisher

Wiley

Subject

Hematology

Reference48 articles.

1. Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice;Angelopoulou;Experimental Hematology,2003

2. Improved regulatory T-cell activity in patients with chronic immune thrombocytopenia treated with thrombopoietic agents;Bao;Blood,2010

3. A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA;Bitzer;Genes & Development,2000

4. Regulation of megakaryocytopoiesis;Caen;Haemostasis,1999

5. A20 in inflammation and autoimmunity;Catrysse;Trends in Immunology,2014

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