DNA damage control: regulation and functions of checkpoint kinase 1

Author:

Smits Veronique A. J.1,Gillespie David A.2

Affiliation:

1. Unidad de Investigación; Hospital Universitario de Canarias; Instituto de Tecnologías Biomédicas; Tenerife Spain

2. Instituto de Tecnologías Biomédicas; Centro de Investigaciones Biomédicas de Canarias; Facultad de Medicina; Campus Ciencias de la Salud; Universidad de La Laguna; Tenerife Spain

Funder

Ministerio de Economía y Competitividad

D. A. Gillespie the IMBRAIN Project

World Wide Cancer Research Project Grant

Gobierno de Canarias

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference75 articles.

1. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint;Liu;Genes Dev,2000

2. Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects;Zachos;EMBO J,2003

3. The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer;Smith;Adv Cancer Res,2010

4. The decision to enter mitosis: feedback and redundancy in the mitotic entry network;Lindqvist;J Cell Biol,2009

5. Rapid destruction of human Cdc25A in response to DNA damage;Mailand;Science,2000

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