Vaccine based on folded receptor binding domain‐PreS fusion protein with potential to induce sterilizing immunity to SARS‐CoV‐2 variants

Author:

Gattinger Pia1ORCID,Kratzer Bernhard2ORCID,Tulaeva Inna13ORCID,Niespodziana Katarzyna14ORCID,Ohradanova‐Repic Anna5ORCID,Gebetsberger Laura5ORCID,Borochova Kristina1,Garner‐Spitzer Erika6ORCID,Trapin Doris2,Hofer Gerhard7,Keller Walter8ORCID,Baumgartner Isabella9,Tancevski Ivan10ORCID,Khaitov Musa1112ORCID,Karaulov Alexander3,Stockinger Hannes5ORCID,Wiedermann Ursula6ORCID,Pickl Winfried F.24ORCID,Valenta Rudolf13411ORCID

Affiliation:

1. Department of Pathophysiology and Allergy Research Division of Immunopathology Center for Pathophysiology, Infectiology and Immunology Medical University of Vienna Vienna Austria

2. Center for Pathophysiology, Infectiology and Immunology Institute of Immunology Medical University of Vienna Vienna Austria

3. Laboratory for Immunopathology Department of Clinical Immunology and Allergology Sechenov First Moscow State Medical University Moscow Russia

4. Karl Landsteiner University of Health Sciences Krems Austria

5. Center for Pathophysiology, Infectiology and Immunology Institute for Hygiene and Applied Immunology Medical University of Vienna Vienna Austria

6. Institute of Specific Prophylaxis and Tropical Medicine Medical University of Vienna Vienna Austria

7. Department of Materials and Environmental Chemistry University of Stockholm Stockholm Sweden

8. Institute of Molecular Biosciences, BioTechMed Graz University of Graz Graz Austria

9. Department of Ophthalmology Medical University Vienna Vienna Austria

10. Department of Internal Medicine II Medical University of Innsbruck Innsbruck Austria

11. NRC Institute of Immunology FMBA of Russia Moscow Russia

12. Pirogov Russian National Research Medical University Moscow Russia

Funder

Austrian Science Fund

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference51 articles.

1. SARS‐CoV‐2 candidate vaccines ‐ composition, mechanisms of action and stages of clinical development

2. COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

3. Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination

4. BarrettJR Belij‐RammerstorferS DoldC et al. Phase 1/2 trial of SARS‐CoV‐2 vaccine ChAdOx1 nCoV‐19 with a booster dose induces multifunctional antibody responses [published correction appears in Nat Med. 2021 Jun;27(6):1113].Nat Med. 2021;27(2):279‐288.

5. Distinguishing features of current COVID-19 vaccines: knowns and unknowns of antigen presentation and modes of action

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