Affiliation:
1. Department of Oral Medicine, Sedation and Imaging, Hadassah Medical Center, Faculty of Dental Medicine Hebrew University of Jerusalem Jerusalem Israel
2. Department of Dermatology Hadassah Medical Center Jerusalem Israel
3. Faculty of Medicine Hebrew University of Jerusalem Jerusalem Israel
Abstract
AbstractObjectiveThe familial type of oral lichen planus (OLP) is rare, with a paucity of data regarding its clinical significance. Our objective was to characterize patients with familial OLP.MethodsFamilies with at least two members diagnosed with OLP were included. Clinical and demographic data and medical history were recorded.ResultsTwenty families, 19 Jewish and 1 Arab, were identified. Of the Jewish families, 57.8% were non‐Ashkenazi, originating mainly from central Asia. Of those with OLP there were 14 males and 23 females with an average age of 49.1. Dyslipidemia, cardiovascular, and thyroid disorders (27.7%, 22.2%, and 16.6%, respectively) were the most common comorbidities. Five patients from five distinct families had oral cancer, two with second primary.ConclusionsTo the best of our knowledge, this is the largest study describing familial OLP. The predominant and common ethnicity of the families with multiple members diagnosed with OLP may imply an ethnic tendency. The higher tendency of hypothyroidism and the high percentage of OSCC among familial OLP patients might be connected to familial OLP and the latter suggests that this population is predisposed to malignant transformation. Thus, this group should be considered as a high‐risk group.
Funder
Israel Cancer Association
Subject
General Dentistry,Otorhinolaryngology
Cited by
1 articles.
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