Donepezil 23 mg in Asian patients with moderate-to-severe Alzheimer's disease

Author:

Han S. -H.1,Lee J. -H.2,Kim S. Y.3,Park K. W.4,Chen C.5,Tripathi M.6,Dash A.7,Kubota N.8

Affiliation:

1. Department of Neurology; Konkuk University Hospital; Seoul South Korea

2. Department of Neurology; University of Ulsan College of Medicine; Asan Medical Center; Seoul South Korea

3. Department of Neurology; Clinical Neuroscience Center & Neurology; Seoul National University Bundang Hospita; Gyeonggi-do South Korea

4. Department of Neurology; Dong-A University College of Medicine; Dong-A University Hospital; Busan South Korea

5. Department of Pharmacology; National University of Singapore and Memory Aging and Cognition Center; National University Health System; Singapore Singapore

6. Department of Neurology; Neuroscience Centre; AIIMS; New Delhi India

7. Regional Medical Advisor; Eisai Pharmaceuticals India Pvt. Ltd.; Mumbai India

8. Clinical Development Eisai Co. Ltd.; Tokyo Japan

Funder

Eisai Co., Ltd

Publisher

Wiley

Subject

Neurology (clinical),Neurology,General Medicine

Reference9 articles.

1. Limited donepezil inhibition of acetylcholinesterase measured with positron emission tomography in living Alzheimer cerebral cortex;Kuhl;Ann Neurol,2000

2. Regional effects of donepezil and rivastigmine on cortical acetylcholinesterase activity in Alzheimer's disease;Kaasinen;J Clin Psychopharmacol,2002

3. Effectiveness and tolerability of high-dose (23 mg/d) versus standard-dose (10 mg/d) donepezil in moderate to severe Alzheimer's disease: a 24-week, randomized, double-blind study;Farlow;Clin Ther,2010

4. International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals For Human Use http://www.ich.org/products/guidelines/efficacy/article/efficacy-guidelines.html

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