Brain structural and functional connectivity and network organization in cerebral palsy: A scoping review

Author:

Jacobs Nina P. T.12ORCID,Pouwels Petra J. W.3,van der Krogt Marjolein M.12,Meyns Pieter4,Zhu Kangdi1,Nelissen Loïs5,Schoonmade Linda J.6,Buizer Annemieke I.127,van de Pol Laura A.5ORCID

Affiliation:

1. Department of Rehabilitation Medicine, Amsterdam UMC Vrije Universiteit Amsterdam Amsterdam the Netherlands

2. Amsterdam Movement Sciences Rehabilitation & Development Amsterdam the Netherlands

3. Amsterdam UMC, Vrije Universiteit Amsterdam Department of Radiology & Nuclear Medicine, Amsterdam Neuroscience Amsterdam the Netherlands

4. REVAL Rehabilitation Research, Faculty of Rehabilitation Sciences Hasselt University Diepenbeek Belgium

5. Department of Pediatric Neurology, Emma Children's Hospital, Amsterdam UMC location Vrije Universiteit Amsterdam the Netherlands

6. Medical Library Vrije Universiteit Amsterdam Amsterdam the Netherlands

7. Emma Children's Hospital Amsterdam University Medical Centers Amsterdam Netherlands

Abstract

AbstractAimTo explore altered structural and functional connectivity and network organization in cerebral palsy (CP), by clinical CP subtype (unilateral spastic, bilateral spastic, dyskinetic, and ataxic CP).MethodPubMed and Embase databases were systematically searched. Extracted data included clinical characteristics, analyses, outcome measures, and results.ResultsSixty‐five studies were included, of which 50 investigated structural connectivity, and 20 investigated functional connectivity using functional magnetic resonance imaging (14 studies) or electroencephalography (six studies). Five of the 50 studies of structural connectivity and one of 14 of functional connectivity investigated whole‐brain network organization. Most studies included patients with unilateral spastic CP; none included ataxic CP.InterpretationDifferences in structural and functional connectivity were observed between investigated clinical CP subtypes and typically developing individuals on a wide variety of measures, including efferent, afferent, interhemispheric, and intrahemispheric connections. Directions for future research include extending knowledge in underrepresented CP subtypes and methodologies, evaluating the prognostic potential of specific connectivity and network measures in neonates, and understanding therapeutic effects on brain connectivity.

Funder

Horizon 2020 Framework Programme

Fonds Wetenschappelijk Onderzoek

Publisher

Wiley

Subject

Neurology (clinical),Developmental Neuroscience,Pediatrics, Perinatology and Child Health

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