Acinar cell NLRP3 inflammasome and gasdermin D (GSDMD) activation mediates pyroptosis and systemic inflammation in acute pancreatitis

Author:

Gao Lin1,Dong Xiaowu2,Gong Weijuan34,Huang Wei5,Xue Jing6,Zhu Qingtian3,Ma Nan1,Chen Weiwei1,Fu Xianghui7ORCID,Gao Xiang8,Lin Zhaoyu8,Ding Yanbing3,Shi Juanjuan6,Tong Zhihui1,Liu Tingting5,Mukherjee Rajarshi9,Sutton Robert9,Lu Guotao3,Li Weiqin12ORCID

Affiliation:

1. Center of Severe Acute Pancreatitis (CASP), Department of Critical Care Medicine, Jinling Hospital Medical School of Nanjing University Nanjing China

2. Center of Severe Acute Pancreatitis (CASP), Department of Critical Care Medicine, Jinling Hospital Nanjing Medical University Nanjing China

3. Pancreatic Center, Department of Gastroenterology Affiliated Hospital of Yangzhou University, Yangzhou University Yangzhou China

4. Jiangsu Co‐innovation Centre for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine Yangzhou University Yangzhou China

5. Department and Laboratory of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China‐Liverpool Biomedical Research Centre, West China Hospital Sichuan University Chengdu China

6. State Key Laboratory of Oncogenes and Related Genes, Stem Cell Research Centre, Ren Ji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China

7. Division of Endocrinology and Metabolism, State Key Laboratory of Biotherapy, West China Hospital Sichuan University and Collaborative Innovation Centre of Biotherapy Chengdu China

8. State Key Laboratory of Pharmaceutical Biotechnology, Department of Hepatopancreatobiliary Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Centre Nanjing University Nanjing China

9. Liverpool Pancreatitis Research Group, Liverpool University Hospitals NHS Foundation Trust and Institute of Translational Medicine University of Liverpool Liverpool UK

Funder

Jiangsu Provincial Key Research and Development Program

National Natural Science Foundation of China

Publisher

Wiley

Subject

Pharmacology

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