Gender disparities in preterm neonatal outcomes

Author:

O'Driscoll David N.1,McGovern Matthew1ORCID,Greene Catherine M.2,Molloy Eleanor J.134

Affiliation:

1. Paediatrics, Academic Centre Tallaght Hospital Trinity College and Trinity Translational Medicine Institute St James’ Hospital the University of Dublin Dublin Ireland

2. Clinical Microbiology Royal College of Surgeons in Ireland, Education and Research Centre Beaumont Hospital Dublin Ireland

3. Neonatology Coombe Women and Infants’ University Hospital Dublin Ireland

4. Neonatology Our Lady's Children's Hospital Dublin Ireland

Abstract

AbstractAimFrom birth to old age, males generally have poorer disease outcomes compared to females. Preterm infants display a marked gender disparity in disease outcomes, and the underlying mechanisms are not well delineated. Our aim was to review the literature on clinical outcomes between preterm infants of different genders and discuss the potential mechanisms underlying the differences observed.MethodsA literature review was undertaken for experimental and clinical research related to gender differences in preterm outcomes.ResultsPreterm male infants appear to have consistently worse outcomes compared to females, and the aetiology of these differences, while mostly undetermined, is likely multifactorial.ConclusionThe male disadvantage in preterm outcomes is likely multifactorial with hormonal, genetic and immunological differences likely playing key roles. Gender is an important variable in preterm outcome and should be considered when designing clinical and experimental research.

Funder

Health Research Board

Publisher

Wiley

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.7亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2025 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3