Affiliation:
1. Department of Human Genetics Guru Nanak Dev University Amritsar Punjab India
2. Beri Maternity Hospital Southend Beri Fertility and IVF Amritsar Punjab India
3. Hartej Hospital Amritsar Punjab India
Abstract
AbstractBackgroundRecurrent miscarriage (RM) is defined as the loss of two or more consecutive pregnancies. A functional SNP, ‐238G>A in the promoter region of TNF‐α, affects the gene transcription activity with implications on human pregnancy. Previous limited studies, linking the TNF‐α ‐238 G>A to the risk of recurrent miscarriage have been inconclusive.Material and methodThe PCR‐RLFP technique was used to evaluate this polymorphism in 199 RM cases and 215 control women from Amritsar, Punjab. For a meta‐analysis, a total of 13 eligible studies (including the present study) comprising 2947 cases and 2933 controls were included. To evaluate the association among different genetic models, odds ratio with a 95% confidence interval (CI) and chi‐square were used.ResultsGenotype and allelic frequency did not differ significantly between both groups (p = .07 and p = .24, respectively). In the present meta‐analysis, a significant association was found with the recessive model (OR‐1.78 CI:1.24–2.55, p = .002).ConclusionAlthough, TNF‐α ‐238 G>A polymorphism did not provide any risk in the case‐control study but provided risk towards the development of RM with the recessive genetic model in the pooled analysis.
Subject
Obstetrics and Gynecology,Reproductive Medicine,Immunology,Immunology and Allergy,Obstetrics and Gynecology,Immunology