Affiliation:
1. Department of Oral and Maxillo‐facial Implantology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology Shanghai China
Abstract
AbstractObjectivesPeriodontitis and peri‐implantitis are oral infectious‐inflammatory diseases associated with oral microbial dysbiosis. Microbiome‐based therapies, characterized by manipulation of the microbiota, are emerging as promising therapeutic approaches to resolve the microbial dysbiosis and associated dysregulation of immune system. This review aims at summarizing recent progress on microbiome‐based therapies in periodontitis and peri‐implantitis, promoting a further understanding of the related therapeutic mechanisms.Subjects and MethodsPertinent literatures focused on microbiome‐based therapies for periodontitis and peri‐implantitis are obtained from PubMed and Web of Science.ResultsIn this article, we review the roles and therapeutic mechanisms of four microbiome‐based therapies, including probiotics, postbiotics, predatory bacteria and phages, and microbiota transplantation, in the management of periodontitis and peri‐implantitis. Challenges facing this field are also discussed, highlighting the areas that require more attention and investigation.ConclusionsMicrobiome‐based therapies may serve as effective treatment for periodontitis and peri‐implantitis. This review presents a new viewpoint to this field.
Funder
National Natural Science Foundation of China
Subject
General Dentistry,Otorhinolaryngology